Showing posts with label sequence and genome analysis. Show all posts
Showing posts with label sequence and genome analysis. Show all posts

Friday, July 22, 2011

New technology could sequence a person''s genome in minutes

 New technology could sequence a person''s genome in minutes
Washington, Dec 21 : Researchers at the Imperial College London scientists are developing technology that could lead to ultrafast DNA sequencing tool within ten years.
The new technology could ultimately sequence a person''s genome in mere minutes, at a fraction of the cost of current commercial techniques.
The research has suggested that scientists could eventually sequence an entire genome in a single lab procedure, whereas at present it can only be sequenced after being broken into pieces in a highly complex and time-consuming process.
Fast and inexpensive genome sequencing could allow ordinary people to unlock the secrets of their own DNA, revealing their personal susceptibility to diseases such as Alzheimer''s, diabetes and cancer.
Joshua Edel, one of the authors on the study from the Department of Chemistry at ImperialCollege London, said: "Compared with current technology, this device could lead to much cheaper sequencing: just a few dollars, compared with 1m dollars to sequence an entire genome in 2007. We haven''t tried it on a whole genome yet but our initial experiments suggest that you could theoretically do a complete scan of the 3,165 million bases in the human genome within minutes, providing huge benefits for medical tests, or DNA profiles for police and security work."
In the new study, the researchers demonstrated that it is possible to propel a DNA strand at high speed using an electrical charge.
Tim Albrecht, another author on the study, said, "The next step will be to differentiate between different DNA samples and, ultimately, between individual bases within the DNA strand (ie true sequencing)."
The findings were published in the journal Nano Letters. (ANI)

Scientists sequence two new strains from E. coli outbreak in Germany

Scientists sequence two new strains from E. coli outbreak in Germany
Washington, June 12 : Two isolates from the current E. coli (Escherichia coli) outbreak in Germany have been sequenced and analyzed in laboratories.
Both strains are now available from Virginia Bioinformatics Institute''s (VBI''s) Pathosystems Resource Integration Center (PATRIC).
In the rush to save lives, many laboratories are analyzing these genomes and providing data to the research community.
The two genomes have been annotated with Rapid Annotation using Subsystem Technology (RAST), making them consistent with the 184 E. coli genomes and the total 2,865 bacterial genomes available at PATRIC.
The proteins conserved across all E. coli have been used to generate a preliminary phylogenetic tree that is based on 166640 characters across 527 genes in 354 taxa.
This tree shows that the two new strains are most closely related to the pathogenic, enteroaggregative strain 559899, which may give additional insight into its origin.
“The PATRIC team is working around the clock to help the scientific community address this emergency. Analyses such as these provide insights into the origin of highly pathogenic strains and potential response strategies,” said Bruno Sobral, PATRIC''s principal investigator. (ANI)